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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T62639 | Microtubule inhibitor 7 | ||
Compounds 17o (IC50= 14.0 nM, NCI-H460) and 17p (IC50= 2.9 nM, NCI-H460) with furan moieties show potent nanomolar levels of cytotoxic activity against various human cancer cell lines. | |||
T3S2372 | 7-epi-Taxol | 7-Epitaxol,7-epi-Paclitaxel | Others , Microtubule Associated |
1. 7-epi-Taxol (7-Epitaxol) is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol. | |||
T9812 | Tubulin inhibitor 24 | Microtubule Associated | |
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization. | |||
T41248 | Thiocolchicine | Microtubule Associated | |
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. | |||
T5749 | 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside | Others , Microtubule Associated |
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. | |||
T50005 | Sertaconazole | Antifungal | |
Sertaconazole is a broad-spectrum antifungal. | |||
T9595 | LP-261 | Microtubule Associated | |
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. | |||
T6665 | Sertaconazole nitrate | FI-7045,Ginedermofix,FI7056,Ertaczo | Antibiotic , Antifungal |
Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections. | |||
T73050 | KIF18A-IN-7 | ||
KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependent ATPase activity of KIF18A. | |||
T79629 | Tubulin polymerization-IN-46 | ||
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/tubulin inhibitor that impedes tubulin polymerization, induces apoptosis, and arrests MCF-7 breast cancer cells in the G2/M phase, exhibiting potent anti-prolif... | |||
T60936 | Tubulin polymerization-IN-24 | ||
Tubulin polymerization-IN-24 (compound HMBA) is a potent inhibitor of tubulin polymerization that increase the GTP hydrolysis rate and inhibits microtubule assembly. Tubulin polymerization-IN-24 induces apoptosis and cel... | |||
T79232 | MARK4 inhibitor 2 | AMPK | |
MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM. It effectively inhibits the growth of human cells, thereby offering potentia... | |||
T70235 | Cemadotin hydrochloride | ||
Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15,... | |||
T83874 | S-72 | ||
S-72 acts as a microtubule polymerization inhibitor, effective in cell-free assays at concentrations of 1, 3, and 10 µM. At nanomolar levels (IC50s = 15.64 and 26.32 nM, respectively), it diminishes the viability of both... |